Cherokee Middle School is accredited by the Southern Association of Colleges and Schools (SACS). Teachers follow the North Carolina Standard Course of Study and the school uses the NC Testing program for 6th-8th students. All classrooms incorporate high speed Internet, wireless Internet, and interactive SMARTBoards to enhance the 21st century skills being taught and modeled in all areas.

Students are taught in a single-gender instruction environment. The 6th, 7th, & 8th grade classrooms are grouped per building floor. The Middle School building is equipped with two computer labs, multi-purpose room for Dance, Family Consumer Science room, and a Chorus/Band room.

Cherokee Middle School empowers students by offering programs such as: Gear Up, Collaboration with the Great Smokey Mountains National Parks Rangers, Robotics, Burroughs Welcome CSI Summer Institute, Immersion, and Beta Club. The Beta Club placed 1st in the state competition; and 3rd nationally.